diff --git a/Cargo.toml b/Cargo.toml
index 36dea9d..01fb0eb 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -15,6 +15,7 @@ default = []
 unstable = []
 guards = ["tower", "futures-core", "pin-project-lite"]
 serde = ["dep:serde", "dep:serde_json"]
+auto-vary = ["futures", "tokio", "tower"]
 
 [dependencies]
 axum-core = "0.4"
@@ -30,9 +31,13 @@ pin-project-lite = { version = "0.2", optional = true }
 serde = { version = "1", features = ["derive"], optional = true }
 serde_json = { version = "1", optional = true }
 
+# Optional dependencies required for the `auto-vary` feature.
+tokio = { version = "1", features = ["sync"], optional = true }
+futures = { version = "0.3", default-features = false, optional = true }
+
 [dev-dependencies]
 axum = { version = "0.7", default-features = false }
-axum-test = "14"
+axum-test = "15"
 tokio = { version = "1", features = ["full"] }
 tokio-test = "0.4"
 
diff --git a/README.md b/README.md
index a7a3ee3..bee8226 100644
--- a/README.md
+++ b/README.md
@@ -23,6 +23,7 @@
   - [Getting Started](#getting-started)
   - [Extractors](#extractors)
   - [Responders](#responders)
+  - [Auto Caching Management](#auto-caching-management)
   - [Request Guards](#request-guards)
   - [Examples](#examples)
     - [Example: Extractors](#example-extractors)
@@ -76,6 +77,8 @@ any of your responses.
 | `HX-Trigger-After-Settle` | `HxResponseTrigger` | `axum_htmx::serde::HxEvent`         |
 | `HX-Trigger-After-Swap`   | `HxResponseTrigger` | `axum_htmx::serde::HxEvent`         |
 
+### Vary Responders
+
 Also, there are corresponding cache-related headers, which you may want to add to
 `GET` responses, depending on the htmx headers.
 
@@ -85,7 +88,7 @@ you need to add `Vary: HX-Request`. That causes the cache to be keyed based on a
 composite of the response URL and the `HX-Request` request header - rather than
 being based just on the response URL._
 
-Refer to [caching htmx docs section](https://htmx.org/docs/#caching) for details.
+Refer to [caching htmx docs section][htmx-caching] for details.
 
 | Header                  | Responder           |
 |-------------------------|---------------------|
@@ -94,10 +97,27 @@ Refer to [caching htmx docs section](https://htmx.org/docs/#caching) for details
 | `Vary: HX-Trigger`      | `VaryHxTrigger`     |
 | `Vary: HX-Trigger-Name` | `VaryHxTriggerName` |
 
+Look at the [Auto Caching Management](#auto-caching-management) section for
+automatic `Vary` headers management.
+
+## Auto Caching Management
+
+__Requires feature `auto-vary`.__
+
+Manual use of [Vary Reponders](#vary-responders) adds fragility to the code,
+because of the need to manually control correspondence between used extractors
+and the responders.
+
+We provide a [middleware](crate::AutoVaryLayer) to address this issue by
+automatically adding `Vary` headers when corresponding extractors are used.
+For example, on extracting [`HxRequest`], the middleware automatically adds 
+`Vary: hx-request` header to the response.
+
+Look at the usage [example][auto-vary-example].
 
 ## Request Guards
 
-__Requires features `guards`.__
+__Requires feature `guards`.__
 
 In addition to the extractors, there is also a route-wide layer request guard
 for the `HX-Request` header. This will redirect any requests without the header
@@ -207,10 +227,11 @@ fn router_two() -> Router {
 ## Feature Flags
 
 <!-- markdownlint-disable -->
-| Flag     | Default  | Description                                                | Dependencies                                |
-|----------|----------|------------------------------------------------------------|---------------------------------------------|
-| `guards` | Disabled | Adds request guard layers.                                 | `tower`, `futures-core`, `pin-project-lite` |
-| `serde`  | Disabled | Adds serde support for the `HxEvent` and `LocationOptions` | `serde`, `serde_json`                       |
+| Flag        | Default  | Description                                                | Dependencies                                |
+|-------------|----------|------------------------------------------------------------|---------------------------------------------|
+| `auto-vary` | Disabled | A middleware to address [HTMx caching issue][htmx-caching] | `futures`, `tokio`, `tower`                 |
+| `guards`    | Disabled | Adds request guard layers.                                 | `tower`, `futures-core`, `pin-project-lite` |
+| `serde`     | Disabled | Adds serde support for the `HxEvent` and `LocationOptions` | `serde`, `serde_json`                       |
 <!-- markdownlint-enable -->
 
 ## Contributing
@@ -233,3 +254,6 @@ cargo +nightly test --all-features
 - **[Apache License, Version 2.0](/LICENSE-APACHE)**
 
 at your option.
+
+[htmx-caching]: https://htmx.org/docs/#caching
+[auto-vary-example]: https://github.com/robertwayne/axum-htmx/blob/main/examples/auto-vary.rs
diff --git a/examples/auto-vary.rs b/examples/auto-vary.rs
new file mode 100644
index 0000000..b7868d5
--- /dev/null
+++ b/examples/auto-vary.rs
@@ -0,0 +1,40 @@
+//! Using `auto-vary` middleware
+//!
+//! Don't forget about the feature while running it:
+//! `cargo run --features auto-vary --example auto-vary`
+use std::time::Duration;
+
+use axum::{response::Html, routing::get, serve, Router};
+use axum_htmx::{AutoVaryLayer, HxRequest};
+use tokio::{net::TcpListener, time::sleep};
+
+#[tokio::main]
+async fn main() {
+    let app = Router::new()
+        .route("/", get(handler))
+        // Add the middleware
+        .layer(AutoVaryLayer);
+
+    let listener = TcpListener::bind("0.0.0.0:3000").await.unwrap();
+    serve(listener, app).await.unwrap();
+}
+
+// Our handler differentiates full-page GET requests from HTMx-based ones by looking at the `hx-request`
+// requestheader.
+//
+// The middleware sees the usage of the `HxRequest` extractor and automatically adds the
+// `Vary: hx-request` response header.
+async fn handler(HxRequest(hx_request): HxRequest) -> Html<&'static str> {
+    if hx_request {
+        // For HTMx-based GET request, it returns a partial page update
+        sleep(Duration::from_secs(3)).await;
+        return Html("HTMx response");
+    }
+    // While for a normal GET request, it returns the whole page
+    Html(
+        r#"
+        <script src="https://unpkg.com/htmx.org@1"></script>
+        <p hx-get="/" hx-trigger="load">Loading ...</p>
+        "#,
+    )
+}
diff --git a/src/auto_vary.rs b/src/auto_vary.rs
new file mode 100644
index 0000000..c8c0729
--- /dev/null
+++ b/src/auto_vary.rs
@@ -0,0 +1,228 @@
+//! A middleware to automatically add a `Vary` header when needed to address
+//! [HTMx caching issue](https://htmx.org/docs/#caching)
+
+use std::{
+    sync::Arc,
+    task::{Context, Poll},
+};
+
+use axum_core::{
+    extract::Request,
+    response::{IntoResponse, Response},
+};
+use futures::future::{join_all, BoxFuture};
+use http::{
+    header::{HeaderValue, VARY},
+    Extensions,
+};
+use tokio::sync::oneshot::{self, Receiver, Sender};
+use tower::{Layer, Service};
+
+use crate::{
+    headers::{HX_REQUEST_STR, HX_TARGET_STR, HX_TRIGGER_NAME_STR, HX_TRIGGER_STR},
+    HxError,
+};
+#[cfg(doc)]
+use crate::{HxRequest, HxTarget, HxTrigger, HxTriggerName};
+
+const MIDDLEWARE_DOUBLE_USE: &str =
+    "Configuration error: `axum_httpx::vary_middleware` is used twice";
+
+/// Addresses [HTMx caching issue](https://htmx.org/docs/#caching)
+/// by automatically adding a corresponding `Vary` header when [`HxRequest`], [`HxTarget`],
+/// [`HxTrigger`], [`HxTriggerName`] or their combination is used.
+#[derive(Clone)]
+pub struct AutoVaryLayer;
+
+/// Tower service for [`AutoVaryLayer`]
+#[derive(Clone)]
+pub struct AutoVaryMiddleware<S> {
+    inner: S,
+}
+
+pub(crate) trait Notifier {
+    fn sender(&mut self) -> Option<Sender<()>>;
+
+    fn notify(&mut self) {
+        if let Some(sender) = self.sender().take() {
+            sender.send(()).ok();
+        }
+    }
+
+    fn insert(extensions: &mut Extensions) -> Receiver<()>;
+}
+
+macro_rules! define_notifiers {
+    ($($name:ident),*) => {
+        $(
+            #[derive(Clone)]
+            pub(crate) struct $name(Option<Arc<Sender<()>>>);
+
+            impl Notifier for $name {
+                fn sender(&mut self) -> Option<Sender<()>> {
+                    self.0.take().and_then(Arc::into_inner)
+                }
+
+                fn insert(extensions: &mut Extensions) -> Receiver<()> {
+                    let (tx, rx) = oneshot::channel();
+                    if extensions.insert(Self(Some(Arc::new(tx)))).is_some() {
+                        panic!("{}", MIDDLEWARE_DOUBLE_USE);
+                    }
+                    rx
+                }
+            }
+        )*
+    }
+}
+
+define_notifiers!(
+    HxRequestExtracted,
+    HxTargetExtracted,
+    HxTriggerExtracted,
+    HxTriggerNameExtracted
+);
+
+impl<S> Layer<S> for AutoVaryLayer {
+    type Service = AutoVaryMiddleware<S>;
+
+    fn layer(&self, inner: S) -> Self::Service {
+        AutoVaryMiddleware { inner }
+    }
+}
+
+impl<S> Service<Request> for AutoVaryMiddleware<S>
+where
+    S: Service<Request, Response = Response> + Send + 'static,
+    S::Future: Send + 'static,
+{
+    type Response = S::Response;
+    type Error = S::Error;
+    type Future = BoxFuture<'static, Result<Self::Response, Self::Error>>;
+
+    fn poll_ready(&mut self, cx: &mut Context<'_>) -> Poll<Result<(), Self::Error>> {
+        self.inner.poll_ready(cx)
+    }
+
+    fn call(&mut self, mut request: Request) -> Self::Future {
+        let exts = request.extensions_mut();
+        let rx_header = [
+            (HxRequestExtracted::insert(exts), HX_REQUEST_STR),
+            (HxTargetExtracted::insert(exts), HX_TARGET_STR),
+            (HxTriggerExtracted::insert(exts), HX_TRIGGER_STR),
+            (HxTriggerNameExtracted::insert(exts), HX_TRIGGER_NAME_STR),
+        ];
+        let future = self.inner.call(request);
+        Box::pin(async move {
+            let mut response: Response = future.await?;
+            let used_headers: Vec<_> = join_all(
+                rx_header
+                    .into_iter()
+                    .map(|(rx, header)| async move { rx.await.ok().map(|_| header) }),
+            )
+            .await
+            .into_iter()
+            .flatten()
+            .collect();
+
+            if used_headers.is_empty() {
+                return Ok(response);
+            }
+
+            let value = match HeaderValue::from_str(&used_headers.join(", ")) {
+                Ok(x) => x,
+                Err(e) => return Ok(HxError::from(e).into_response()),
+            };
+
+            if let Err(e) = response.headers_mut().try_append(VARY, value) {
+                return Ok(HxError::from(e).into_response());
+            }
+
+            Ok(response)
+        })
+    }
+}
+
+#[cfg(test)]
+mod tests {
+    use axum::{routing::get, Router};
+
+    use super::*;
+    use crate::{HxRequest, HxTarget, HxTrigger, HxTriggerName};
+
+    fn vary_headers(resp: &axum_test::TestResponse) -> Vec<HeaderValue> {
+        resp.iter_headers_by_name("vary").cloned().collect()
+    }
+
+    fn server() -> axum_test::TestServer {
+        let app = Router::new()
+            .route("/no-extractors", get(|| async { () }))
+            .route("/hx-request", get(|_: HxRequest| async { () }))
+            .route("/hx-target", get(|_: HxTarget| async { () }))
+            .route("/hx-trigger", get(|_: HxTrigger| async { () }))
+            .route("/hx-trigger-name", get(|_: HxTriggerName| async { () }))
+            .route(
+                "/repeated-extractor",
+                get(|_: HxRequest, _: HxRequest| async { () }),
+            )
+            .route(
+                "/multiple-extractors",
+                get(|_: HxRequest, _: HxTarget, _: HxTrigger, _: HxTriggerName| async { () }),
+            )
+            .layer(AutoVaryLayer);
+        axum_test::TestServer::new(app).unwrap()
+    }
+
+    #[tokio::test]
+    async fn no_extractors() {
+        assert!(vary_headers(&server().get("/no-extractors").await).is_empty());
+    }
+
+    #[tokio::test]
+    async fn single_hx_request() {
+        assert_eq!(
+            vary_headers(&server().get("/hx-request").await),
+            ["hx-request"]
+        );
+    }
+
+    #[tokio::test]
+    async fn single_hx_target() {
+        assert_eq!(
+            vary_headers(&server().get("/hx-target").await),
+            ["hx-target"]
+        );
+    }
+
+    #[tokio::test]
+    async fn single_hx_trigger() {
+        assert_eq!(
+            vary_headers(&server().get("/hx-trigger").await),
+            ["hx-trigger"]
+        );
+    }
+
+    #[tokio::test]
+    async fn single_hx_trigger_name() {
+        assert_eq!(
+            vary_headers(&server().get("/hx-trigger-name").await),
+            ["hx-trigger-name"]
+        );
+    }
+
+    #[tokio::test]
+    async fn repeated_extractor() {
+        assert_eq!(
+            vary_headers(&server().get("/repeated-extractor").await),
+            ["hx-request"]
+        );
+    }
+
+    // Extractors can be used multiple times e.g. in middlewares
+    #[tokio::test]
+    async fn multiple_extractors() {
+        assert_eq!(
+            vary_headers(&server().get("/multiple-extractors").await),
+            ["hx-request, hx-target, hx-trigger, hx-trigger-name"],
+        );
+    }
+}
diff --git a/src/extractors.rs b/src/extractors.rs
index 81ab239..5f25683 100644
--- a/src/extractors.rs
+++ b/src/extractors.rs
@@ -137,6 +137,12 @@ where
     type Rejection = std::convert::Infallible;
 
     async fn from_request_parts(parts: &mut Parts, _: &S) -> Result<Self, Self::Rejection> {
+        #[cfg(feature = "auto-vary")]
+        parts
+            .extensions
+            .get_mut::<crate::auto_vary::HxRequestExtracted>()
+            .map(crate::auto_vary::Notifier::notify);
+
         if parts.headers.contains_key(HX_REQUEST) {
             return Ok(HxRequest(true));
         } else {
@@ -164,6 +170,12 @@ where
     type Rejection = std::convert::Infallible;
 
     async fn from_request_parts(parts: &mut Parts, _: &S) -> Result<Self, Self::Rejection> {
+        #[cfg(feature = "auto-vary")]
+        parts
+            .extensions
+            .get_mut::<crate::auto_vary::HxTargetExtracted>()
+            .map(crate::auto_vary::Notifier::notify);
+
         if let Some(target) = parts.headers.get(HX_TARGET) {
             if let Ok(target) = target.to_str() {
                 return Ok(HxTarget(Some(target.to_string())));
@@ -193,6 +205,12 @@ where
     type Rejection = std::convert::Infallible;
 
     async fn from_request_parts(parts: &mut Parts, _: &S) -> Result<Self, Self::Rejection> {
+        #[cfg(feature = "auto-vary")]
+        parts
+            .extensions
+            .get_mut::<crate::auto_vary::HxTriggerNameExtracted>()
+            .map(crate::auto_vary::Notifier::notify);
+
         if let Some(trigger_name) = parts.headers.get(HX_TRIGGER_NAME) {
             if let Ok(trigger_name) = trigger_name.to_str() {
                 return Ok(HxTriggerName(Some(trigger_name.to_string())));
@@ -222,6 +240,12 @@ where
     type Rejection = std::convert::Infallible;
 
     async fn from_request_parts(parts: &mut Parts, _: &S) -> Result<Self, Self::Rejection> {
+        #[cfg(feature = "auto-vary")]
+        parts
+            .extensions
+            .get_mut::<crate::auto_vary::HxTriggerExtracted>()
+            .map(crate::auto_vary::Notifier::notify);
+
         if let Some(trigger) = parts.headers.get(HX_TRIGGER) {
             if let Ok(trigger) = trigger.to_str() {
                 return Ok(HxTrigger(Some(trigger.to_string())));
diff --git a/src/lib.rs b/src/lib.rs
index 439ff68..fc1bd36 100644
--- a/src/lib.rs
+++ b/src/lib.rs
@@ -5,6 +5,9 @@
 mod error;
 pub use error::*;
 
+#[cfg(feature = "auto-vary")]
+#[cfg_attr(feature = "unstable", doc(cfg(feature = "auto-vary")))]
+pub mod auto_vary;
 pub mod extractors;
 #[cfg(feature = "guards")]
 #[cfg_attr(feature = "unstable", doc(cfg(feature = "guards")))]
@@ -12,6 +15,10 @@ pub mod guard;
 pub mod headers;
 pub mod responders;
 
+#[cfg(feature = "auto-vary")]
+#[cfg_attr(feature = "unstable", doc(cfg(feature = "auto-vary")))]
+#[doc(inline)]
+pub use auto_vary::*;
 #[doc(inline)]
 pub use extractors::*;
 #[cfg(feature = "guards")]